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不同“蓝耳病”(PRRS)疫苗的免疫效果——抗体

2011-04-11

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不同“蓝耳病”(PRRS)疫苗的免疫效果——抗体效价分析

ZHUFANZHIYUHUXIZONGHEZHENG(JIANCHENGPRRS,SUCHENGZHU“LANERBING”)KUNRAOYEJIEYIYOUSHIYUNIANZHIJIU,QIJINWEIZHI,QUANQIUFANWEINEIDUIGAIBINGRENGWULINGRENXINFUDEPANDUANYUKONGZHIFANGAN,ZHIJIEHUOJIANJIEJIYANGZHUYEZAOCHENGWUFAGULIANGDESUNSHI。ZAIWOGUO,YOUYUJINNIANLAIZHENGFUZHUGUANBUMEN、BUFENZHULIUPAIZHUBINGZHUANJIAJIGUONEIWAIZHONGDUOYIMIAOSHENGCHAN、XIAOSHOUZHEBALINCHUANGSHANGYOU“GAORE”ZHENGZHUANGHUOJU“GAOZHIBINGXING”LIUXINGTEZHENGDEYIBINGHEZHUFANZHIYUHUXIZONGHEZHENGBINGDU(JIANCHENGPRRSV)GANRANLIANXIZAIYIQI,SHIBENLAIYIXIANGDANGFUZADEZHUBINGYUZHENGZHI、SHANGYE、XUESHUJIQITAZHUDUOYINSUYOUYIHUOWUYIDIJIEHEZAIYIQI,XINGCHENGGENGDUOCUOZONGFUZADEMITUAN。QIZHONGYEJIEDUIGEZHONGPRRSYIMIAOSHIYONGXIAOGUODEJINGRENCHENMOTAIDUKENENGSHIZUIZHIDEFANSIDEWENTIZHIYI。

ZHONGSUOZHOUZHI,PINGJIAYIMIAODESHIYONGXIAOGUOYOUGEZHONGBUTONGDEDINGXINGHUODINGLIANGZHIBIAO,DANDUIRENHEYIZHONGYIMIAOERYAN,KANGTIXIAOJIAJIANCESHIZUIQIMADE、BUKEHUOQUEDEJIBENBUZHOU。RANERJINNIANLAI,YOUYUSHOUDUOZHONGYINSUDEWUDAO,DADUOSHUYONGHUDUIPRRSYIMIAODEXIAOGUOPANDUANZHITINGLIUZAIZHUQUNJIEZHONGYIMIAOHOUSHIFOUHUIFABING、SHIFOUHUIDAOZHILIUCHANHUOSITAIDENG“ZHIBINGXING”FUZUOYONGCUNZAIYUFOUDESHUIPINGSHANG。ZAIPRRSYIMIAOXIAOGUOPINGJIAWENTISHANG,QUANGUOFANWEIDE“JITISHIYUZHENG”MANYANLINGYANGZHUYEJIZHENGGEJINGJISHEHUIFUCHULECHENZHONGDEDAIJIA。

WEICI,BIZHEDUIRUOGANGEGUANLIJIAOGUIFAN、ZHUQUNBIAOGUANJIANKANG、SHENGCHANQINGKUANGJIAOWENDING、SHENGCHANXINGNENGJIAOHAO、YIMIAOSHIYONGQINGKUANGKEZHUISHUODEZHUCHANGSHIYONGBUTONGLAIYUANPRRSYIMIAOHOUDEKANGTIJIANCEQINGKUANGZUOFENXI,GEBIEWEINENGZUOKANGTIXIAOJIAFENXIDEANLIZEYILINCHUANGZHENGZHUANGMIAOSHUWEIZHU,BINGYUCONGWEISHIYONGGUOCILEIYIMIAOZHUQUNDEKANGTISHUIPINGZUOBIJIAO,WEIYENEIRENSHITIGONGCANKAOSUCAI。

一、进口PRRS弱毒疫苗的抗体效价检测结果分析

GUANGDONGJIANGMENSHIMOUZHUCHANG(CUNLAN800TOUMUZHU),2007NIAN3YUEFENQIZHANGQISHIYONGDEGUOMOUGONGSISHENGCHANDEPRRSRUODUMIAO,ZHONGZHUQUNMEI3GEYUETONGMIANYICI,SHANGPINZHU14TIANLINGJIEZHONGYICI。MEI4~5GEYUEDUIGEJIEDUANZHUQUNANBILICHOUQUXUEYANG,SONGNONGYEBU(GUANGZHOU)ZHONGZHUZHILIANGJIANDUJIANYANCESHIZHONGXINJIYINFENXISHIYANSHIZUODUOZHONGYIMIAOKANGTIXIAOJIAJIANCE。ZUIJINYICI(2008NIAN4YUE)DEPRRSVKANGTIXIAOJIAJIANCEJIEGUORUBIAOYIJITUYI。

GAIJIEGUO(YUGUOQUBANNIANDEJIANCEJIEGUOLEISI)BIAOMING,JINGUANZHONGZHUQUNMEISANGEYUEJIEZHONGYICIPRRSJINKOURUODUMIAO,DANRENGYOUJIN27%ZHUZHIDEKANGTISHUIPINGZAI“YINXING”FANWEI;ER30~90TIANLINGDEXIAOZHUJIHUKANBUDAOYOUTONGJIXUEYIYIDEKANGTIZHIBIAO;CONGYIMIAOFANYINGCHANGSHIPANDUAN,120TIANLINGYISHANGDAZHUDEKANGTIFANYING(YANGXINGLV62.5%)HENNANYU14TIANLINGSHIJIEZHONGYIMIAOGUAGOU,YUQISHUOSHIYIMIAOFANYINGJIEGUOBURUSHUOSHIYEDUGANRANJIEGUOGENGLINGRENXINFU。

ZHIDEYITIDESHI,GAICHANGSHIYONGSHANGSHUPRRSYIMIAOMIANYIFANGANSANGEYUENEI,ZHUQUNSHENGCHANXINGNENGRENGWEIJIANYOURENHEBIANHUA,XIANGDANGZHANGSHIJIANNEIXIAOZHUSIWANGLVWEICHIZAI20%ZUOYOU,MUZHUPEIZHONGFENMIANLVJIN70%ZUOYOU。CONG2007NIAN6YUEQISHIYONGFUYUANKANGAMIANYIDIAOJIEJIHOU,ZHUQUNJIANKANGSHUIPINGYIGEYUENEIXIANZHUGAISHAN,SANGEYUEHOUSHENGCHANXINGNENGCHUANGLISHIZUIHAOSHUIPING,BINGYIZHIBAOCHIZHIJIN:QUANCHANGYUEJUNSITAOLV1.5%ZUOYOU,ZHONGZHUPEIZHONGFENMIANLV90%YISHANG,QUANCHANGYONGYAOCHENGBENCONG3WANDUOYUANJIANGZHIBUZU3QIANYUAN,SHENGZHANGZHUCHULANSHIJIANTIQIAN15TIANYISHANG。

表一 进口PRRS弱毒疫苗抗体效价分析

DONGWU

JIANCEYANGBENSHU

PRRSVKANGTIYANGXINGLV*(%)

ZHONGZHU

26

73.1(19/26)

20.0(3/15)

62.5(5/8)

34.8(8/23)

55.1(27/49)

XIAO、ZHONGZHU(30~90TIANLING)

15

DAZHU(120~150TIANLING)

8

SHENGZHANGZHULEIJI(30~150TIANLING)

23

BENCIYANGPINZONGJI

49

*SHUOMING:BENWENPRRSVKANGTIJUNYONGMEIGUOIDEXXGONGSISHIJIHECEDING,S/PZHI≥0.4ZHEWEIYANGXING,S/PZHI<0.4ZHEWEIYINXING。


图三 未使用任何PRRS疫苗的公猪抗体效价检测结果(S/P值)

ANLIER:GUANGDONGZHAOQINGMOUZHUCHANG(CUNLANMUZHU600TOU),CONGWEISHIYONGRENHEPRRSYIMIAO,SUIJICHOUQU8TOUYOULIUCHANZHENGZHUANG(YISI“ZHULIUGAN”)DEJINGCHANMUZHUXUEYANGZUOPRRSVJIYINJIANCEJIKANGTIJIANCE,PCRJIANCEBIAOMINGYEDUGANRANJIEGUOQUANBUWEIYINXING,KANGTIYANGXINGLVWEI62.5%(5/8)。

ANLISAN:GUANGDONGFOSHANMOUCHANG(CUNLANMUZHU300TOU),GAICHANGJIQIHOUBEIMUZHULAIYUANCHANGCONGWEIJIEZHONGRENHEPRRSYIMIAO,2007NIAN12YUECHU,YIZHOUNEILIANXUFASHENG7TOUQINGTAI(30~40TIANTAILING)MUZHULIUCHAN,LIUCHANMUZHU3~5TIANNEIQUANBUZHONGXINFAQINGPEIZHONGBINGSHOUTAI,SUIJIZUODUOXIANGXUEQINGXUEZHIBIAOJIANCE,PRRSVKANGTIYANGXINGLVWEI100%(7/7),YIWEIFAXIANRENHEZHUWEN、WEIKUANGQUAN、YUANHUANBINGDUDENGYEDUGANRAN,HOUJINGFENXIYIWEIMEIJUNDUSUZHONGDUDAOZHILIUCHAN。

CONGZHEISANGEJIAOYOUDAIBIAOXINGDEPRRSFEIMIANYIZHUQUNDEPRRSVKANGTIXIAOJIACEDINGJIEGUOCHONGFENXIANSHI,PRRSVYEDUGANRANYIXIANGDANGPUBIAN,QIEYINYEDUGANRANERZHIDEKANGTIYANGXINGLVBIJIEZHONGYIMIAOZHUQUNDEKANGTIYANGXINGLVHAIGAO。DANCONGZHEIXIEFEIMIANYIZHUQUNDEWENDINGJIANKANGZHUANGKUANGHEYUANCHAOQITATONGLEIZHUCHANGDESHENGCHANXINGNENGZHIBIAOLAIKAN,YEDUBINGFEIDOUSHIZHEILIANGNIANYEJIEPUBIANRENWEIDE“QIANGDU”,ERQIEWANQUANKEYITONGGUODIAOZHENGZHUQUNDEFEITEYIXINGMIANYIGONGNENGLAIDADAO“YULANGONGWU”DEWENDINGZHUANGKUANG。ERSHENGCHANSHANGOUJIANDEFEIPRRSMIANYIZHUQUNWUGUILVXINGDEMUZHULIUCHANHENKENENGSHIYOUYUCHANGJIANDEMEIJUNDUSUZHONGDU、YISI“ZHULIUGAN”YIJISUIZHIERLAIDEBUDANGYAODECHULI、HUOQITABINGDUHUOXIJUNGANRANZAOCHENG,ERFEIPUBIANRENWEI“LANERBING”ZAOCHENG。

五、讨论

1、PRRSSHIQUANQIUYANGZHUYEDENANTIZHIYI,WUSHUZHUANJIAHAOFEIDALIANGJINGLIZHIJINRENGWEINENGZHAODAOLINGRENXINFUDELINCHUANGPANDUANHUOKONGZHICUOSHI。ERJINNIANLAI,WOGUOYANGZHUYEJIESHANGZHIZHULIUPAIDINGJIZHUANJIA,XIAZHIZHUCHANG“XIANGJIANSHOUYI”,FANJIAN“ZHIDUANFAGAN”、“QUANSHENCHAOHONG”、“GAOREBUTUI”、MUZHUBUGUIZELIUCHANDENGLINCHUANGZHENGZHUANGZHEGAICHENGWEI“LANERBING”,ZHIDEYEJIETONGRENSHENSI。

2、YENEIRENSHIPUBIANRENWEIWOGUOSHENZHIQUANYAZHOUFANWEINEIJIHUWUFAZHAODAOJIGEWEISHOUPRRSVGANRANDEZHUCHANG。ZAIBIAOGUANJIANKANGZHUCHANGYICHANGKEFENLICHUPRRSBIANYIZHU,DANBINGFEISUOYOUZHUCHANGDOUFABING,GENGBUHUITONGSHIFABING。YINCI,SIHUYONGJIANDANDELUOJITUILIJIKEZHENGMING,JINNIANLAICIQIBIFUDE“GAOZHIBINGXING”ZHUBINGYUPRRSGANRANWUBIRANLIANXI。

3、BAOKUOBIZHEZAINEIDEBUSHAOYENEIRENSHIRENWEI,BAJINNIANCIQIBIFUDELIUXINGXINGZHUBINGDINGYIWEI“GAOZHIBINGXINGLANERBING”,ZHIJINWEIZHIQUEFALINGRENXINFUDELIJU。GEDIJIEZHONG“GAOZHIBINGXINGLANERBINGYIMIAO”BUDANWEIJIANYUQIXIAOGUO,GENGDUODESHICHANSHENGYANZHONGDEFUZUOYONG,ZAOCHENGYANZHONGJINGJISUNSHI。

4、JINNIANLAI,YINJIEZHONGGEZHONGGEYANGPRRSYIMIAO(BAOKUOGUONEISHENGCHANJIGUOWAIJINKOU、YOUHEFASHOUXUHUOFEIFASHENGCHAN、YIJITOUYUNRUJING、MEIZHOUDUZHUHUOOUZHOUDUZHU、YIBANDUZHUHUO“GAOZHIBINGXING”DUZHU、YIJIBUWENQINGHONGZAOBAIDE“ZIJIAMIAO”)ERZHIZHUQUNBUTONGCHENGDUSHOUSUNDEANLIBUSHENGMEIJU,BIZHECENGCULVEGUJI,ZHEILIANGNIANSUNSHIDEJUESHULIANGDEZHUZHI(HANLIUCHAN、SITAIJIBUFAQING)60%YISHANGYUJIEZHONGGEZHONGPRRSYIMIAOYOUZHIJIEGUANXI。ZHIYINZHUQUNZAIJIEZHONGYIMIAOQIANDEJIANKANGZHUANGKUANGNANYILIDING、BUTONGDONGWUQUNTISHIYONGYIMIAOHOUFANYINGDEKEBIXINGCHA、YIMIAODEYICIXINGSHIYONGDESHANGPINTEXING、YIJISIFAQUZHENGJIPANDINGCHENGXUDEHUISEZHUANGTAI,DENGZHONGDUOYUANYINLINGSHOUHAIZHECHUYUBULIDIWEI。CHANGSHUNSIFATUJINGDEJIANLIKENENGSHIEZHIFEIFA、JIAMAOWEILIEJIYOUHAIDEYIMIAOHESHOUYAODEYOUXIAOCHENGXUZHIYI。

5、SHANGSHURUOGANJIEZHONGBUTONGLAIYUANDEPRRSYIMIAODEZHUQUNKANGTIJIANCEJIEGUOBIAOMING,MIANYIZHUQUNDEKANGTISHUIPINGBINGBUBIFEIMIANYIZHUQUNDEKANGTISHUIPINGGAO;QIEQIKANGTIDIDUDELISANXINGYUANBIFEIMIANYIZHUQUNGAO,ZHEIDUIZHUQUNDEJIANKANGWENDINGXINGKENENGSHIGEGENGDADEQIANZAIWEIXIE。

6、CONGBENGUANCHAJIEGUOBIAOMING,PRRSMIANYICHANGDEYOULINGZHUQUNWEIJIANDAORENHEYOUXIAODEMUYUANKANGTIJIXIANG。ZHEIJIUJINGSHICILEIYIMIAOGENBENBUNENGCHANSHENGYOUXIAOKANGTI?HAISHICILEIKANGTIBUNENGTONGGUOMURUFENMI?YIHUOSHICILEIMUYUANKANGTIZAIYOUCHUXIAOHUADAOBEIFENJIEERWUFAJINRUXUEYEXUNHUAN?HAISHIMUYUANKANGTIJINRUYOUCHUTINEIHOUHENKUAIBEIHAOJIN,ZHIDEZHUANJIAMENJINYIBUYANZHENG。

7、YOULINGZHUQUN(2~3ZHOU)JIEZHONGPRRSRUODUYIMIAOHUOMIEHUOMIAOHOUZHANGSHIJIAN(70~80TIAN)NEIWEINENGJIANCEDAOYOUYIYIDEKANGTISHUIPING。ZHEIZHISHAOBIAOMINGCILEIYIMIAOZAIDASHENGCHANTIAOJIANXIADUIYOULINGDONGWUWANQUANMEIYOURENHEXIAOGUO;SHENGZHANGZHONGHOUQI(90TIANLINGHOU)BUFENGETIJIANCEDAODEKANGTIXIAOJIABUPAICHUSHIYEDU(YEDUBUYIDINGJUNWEIQIANGDU)ZIRANGANRANDEJIEGUO。

8、QIJINWEIZHI,WURENHEFANGFAQUFENDONGWUTINEIDEPRRSV KANGTISHIJIEZHONGYIMIAODEJIEGUOHAISHIYEDUGANRANDEJIEGUO,ZHEIJIMIANYIXIAOGUODEPINGJIAZENGJIALENANDU;YOUYANJIUZHERENWEI,ZHUQUNFABINGYUFOU,YUPRRSVKANGTISHUIPINGMEIYOUZHIJIEXIANGGUANXING,BUFENYUANYINKENENGYUCIYOUGUAN。

9、JUBAODAO,PRRSVDEJIYINXINGHUOXUEQINGXINGHENDUO,DUZHUJIANJIHUMEIYOUJIAOHUMIANYILI;RUODUYIMIAOMEIYOUJIAQIANGMIANYIFANYING;QIJINWEIZHIWEIJIANMIEHUOYIMIAOYOUXIAODELINGRENXINFUDEKEGUANBAOGAO。YINCI,ZHIWANGTONGGUOJIEZHONGYIMIAODETUJINGLAIKONGZHIPRRSKENENGXINGYOUDUODA,KENENGSHIGEXUYAOZHONGXINZUOYANJINDINGWEIDEFANGXIANGXINGWENTI。FOUZE,FANGXIANGCUOLE,ZUODEYUEDUOCUODEYUEDUO,ZOUDEYUEKUAILIMUBIAOYUEYUAN。

10、BENWENLIESHUDERUOGANGECONGWEIJIEZHONGRENHEPRRSYIMIAODEZHUCHANG,YOUYUCAIQULEYOUXIAODEGUANLIJIMIANYIDIAOJIECUOSHI(ZHANGQISHIYONGFUYUANKANGMIANYIDIAOJIEJI),QIJINWEIJIANDIANXINGDEPRRSZHENGZHUANG,ZHUCHANGSHENGCHANXINGNENGXIANZHUYOUYUDADUOSHUQITAZHUCHANG。

11、BIZHERENWEI,ZONGGUANWOGUOJINSHILAINIANDEZHUBINGBIANHUAQINGKUANG,ZHISUOYIBUDUANCHUXIANCIQIBIFUDEJIHUWUFAKONGZHIDEZHONGDAYIBING,SHIYOUYUZHENGGEYANGZHUYEDEXITONGZAIBUZHIBUJUEZHONGCHULEDAWENTI,BAOKUOYINZHONG(JIHUBUCUNZAIZHENZHENGYOUKEXUEYIYIDEYUZHONG)、SIYANGGONGYI(XIANSHIYUANFEIKEYITAOLUNSIYANGMOSHIDESHIJI)、SILIAOYUANLIAOJIGEZHONGTIANJIAWUDELAIYUANJISILIAOJIAGONG、SIYANGYUYINGYANG、YIBINGFANGZHI(HANYIMIAOJISHOUYAOSHENGCHANYUYINGYONG)、NEIWAIHUANJINGDIAOKONGDENGGEFANGMIANJUNXUZUOSHENKEFANSI。RANERZHIJINWEIZHI,ZAIKONGZHIZHUQUNJIANKANGDEWENTISHANG,YEJIEJIBENSHANGZHICAIQUJIUSHILUNSHIDESIWEIFANGSHI。BIZHERENWEI,DUIZHONGDUOYUANSUDEMOUGEBUFENZUOXIUBUGONGZUOHENNANGAIBIANZHENGGEXITONGDEYUNZUO。JIANERYANZHI,ZHUQUNXIANGDANGPUBIANDEMIANYIWENLUANZHUANGKUANGSHIZHUBINGWUFAKONGZHIDEGENYUAN,ERSHANGSHUGEFANGMIANDUOGEHUANJIECUNZAIDEWENTIDOUSHIZHIJIEHUOJIANJIEZAOCHENGMIANYIWENLUANDEYUANYIN。YINCI,YAODADAOJIANKANGGAOXIAOYANGZHUDEMUDE,RENZHONGERDAOYUAN。

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来源:本文刊登在《养猪》2008年第4期70-72页