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学术与应用

仔猪先天性震颤综合征病因分析与解决方案

【来源】本刊登在《养猪》2008年第6期 【作者】梁皓仪、李成彦 【日期】2008-11-08 【关键词】福源康,保健药物,饲料添加

YANGZHUSHENGCHANSHANGZIZHU“XIANTIANXINGZHENZHAN”(congenital tremors)ZHENGZHUANG(CHANGBEICHENGZUO“CHUSHENGZIZHUDOUDOUBING”、“XINSHENGZIZHUTIAOTIAOBING”,HUO“ZIZHUXIANTIANXINGZHENZHANZONGHEZHENG”)SHIYOUFASHENG,YOUYUGUANCHADEJIAODUHUOCENGMIANBUTONG,BUTONGGUANCHAZHEDUIBINGYINFENXICHANGHUIDECHUGEZHONGBUTONGDEPANDUANHUOJIELUN,JIAOCHANGJIANDEPANDUANYOUHUANJINGYINSU(DIWEN)、YICHUANQUEXIAN(ZHUYAOLAIZIXIONGXINGJIYIN)、YINGYANGSUQUEFA(NENGLIANG、WEISHENGSU、KUANGWUYUANSU)、XIJUN(POSHANGFENGGANJUN、LIANQIUJUN、SHIXUEGANJUN、FEIYANZHIYUANTI)HUOBINGDU(WEIKUANGQUANBINGDU、YUANHUANBINGDUIIXING、ZHUWENBINGDU、“LANER”BINGDU、NAOJISUIYANBINGDU、XIXIAOBINGDU)GANRANJIMEIJUNBINGDUZHONGDU,YIYOURENRENWEIYUZHUWENDECHAOQIANMIANYIDAOZHISHENJINGXITONGSHOUSUNYOUGUAN,SHENZHIYOURENRENWEISHIYIZHONGXINDECHUANRANBINGBINGJIAYIZHUIZONGYANJIU。YOUXUEZHERENWEISHIBINGZHUZHONGSHUSHENJINGXITONGDESHENJINGXIANWEISUIQIAOFAYUCUNZAIQUEXIAN,BINGYINCIDAOZHISHENJINGDIZHICHUANDAOZHANGAIERCHANSHENGGONGJISHIDIAODEZHENZHANZHENGZHUANG。RANER,ZHANGQIYILAIDEGEZHONGLUNDUANSIHUJUNNANDACHENGGONGSHI,QIEJIHUMEIYOULINGRENXINFUDEANLIKEYIZAISHIYANSHIFUZHICHULAI;GENGYOUYUCIBINGSHANGWEIGUANCHADAOSHUIPINGCHUANBODEDIANXINGANLI,SIWUGUILVDEFABINGANLIHENSHAOYINQIXUEZHEDEYANJIUXINGQU,YINERSHENGCHANSHANGDEBINGLIRENGRANSHIYOUFASHENG,SUNSHIBUKEDIGU。

WEINONGQINGCHUSHENGZIZHUXIANTIANXINGZHENZHANDEFABINGYUANYIN,BINGTANTAOQUESHIYOUXIAODEJIEJUEFANGAN,JINNIANLAI,BIZHECENGDUIDUOGEDAXINGZHUCHANGZUOGENZONGTANTAO,YIHANDESHIZHUCHANGHUOMIAOSHUBUZHUNQUE、HUOJILUBUWANQUAN、HUOSUOCAIQUCUOSHIGUOYUFUZAERZAOCHENGHUNLUAN、HUODUOZHONGLINCHUANGXIANXIANGWUFAHUXIANGYINZHENGDENGYUANYINERSHIQUFENXIJIAZHI。2008NIANCHU,ZAIYUMOUXIAOXINGZHUCHANG(CUNLANMUZHUYUE300TOU)CHUXIANLEISIZHENGZHUANG,YINGAICHANGGUANLIRENYUANPEIHELIANGHAO、GUANCHAXIZHI、JILUZHUNQUE,JINGCHULIFENXIHOUDEDAODEJIELUNMINGXIKEXIN,SHUOMINGLIQIANG,XIANGQINGBAOGAORUXIA:

一、病猪表现概况

1、发病时间

SHOUFABINGLICHUXIANYU2008NIAN3YUE28RI,ZHONGJIEBINGLIYUTONGNIAN8YUE20RIZHI,LISHIJIN5GEYUE。

2、临床表现

BINGZHUCHUSHENGHOUSHUFENZHONGNEIJICHUXIANGONGJISHIDIAODEZHENZHANZHENGZHUANG,ZHENGZHUANGZHONGZHEJIBENSHIQUSHENGCUNNENGLI,SHUXIAOSHIZHISHURINEISHUAIXIEERSI;ZHENGZHUANGQINGZHERENGKEZIZHUHUOZAISIYANGYUANBANGZHUXIAXISHUNMURU,DANJIYIGANRANXIAOHUADAOJIBING,QIEYIBANYUHOUBULIANG,DADUOSHUBINGZHUZAIDUANNAIQIANSIWANG;SHAOBUFENZHENGZHUANGJIAOQINGZHE,ZAISANZHOULINGHOUZHENGZHUANGZHUJIANJIANQING,DANZHUANRUBAOYUSHEHOUDUOCHENGWEICANCIBINGZHUZUIZHONGZAOTAOTAIHUOSIWANG,JISHAOSHUKEZHUANRUSHENGZHANGYUFEIJIEDUANDEBINGZHU,ZHENGCHANGQINGKUANGXIAWUKEJIANZHENGZHUANG,DANSHENGZHANGFAYUCHIHUAN,QIEOUYUYINGJISHIRENGBIAOXIANCHUQUANSHENGONGJISHIDIAODEZHENZHANZHENGZHUANG。CIZHONGYIQUANSHENZHENZHANWEITEZHENGDEXIANTIANXINGSHENJINGQUEXIANZHENGZHUANGSIHUBANSUISHOUSUNDONGWUDEZHONGSHENG。

3、发病时机

SHANGSHUBINGZHUDEFABINGSHIJIYOUYIGESHIFENMINGXIANDETEZHENG,JIBINGZHUZHIYOUZAIXINGJUEZHUANGTAIXIACAICHUXIANZHENZHANZHENGZHUANG,JINRUSHUIMIANZHUANGTAIHOUWUROUYANKEJIANZHENGZHUANGCHUXIAN。

4、发病比例

ZAIJIN5GEYUEDEFABINGSHIJIANNEI,GAICHANGGONGYOU76WOCHUSHENGZIZHUFABING,QIZHONG71WOWEICHUCHAN(ZHANGAISHIQICHUCHANMUZHU95%YISHANG)5WOWEIDI2TAILING,QITATAILINGMUZHUSUOCHANZIZHUWEIJIANLEISIZHENGZHUANG。FABINGZHUZHIZHANYOUWENTITAICICHUSHENGHUOZISHU50%ZUOYOU,BINGZHUZAIBURUQIDESITAOLVDA90%ZUOYOU,QIYU5%ZUOYOUDESITAOLVFASHENGZAIYUCHENGQI。

二、病因分析

JIANYUZHUQUNFABINGQINGKUANGRIJIANYANZHONG,4YUEDIQIZHELIYANJIUFABINGYUANYIN,XIANHOUPAICHUHUANJINGYINSU、YINGYANGYINSU、YICHUANQUEXIAN、MEIJUNDUSUZHONGDU、XIJUNGANRANJIWEIKUANGQUANBINGDUGANRANDEKENENGXING。ZHUISUGAICHANGZAITONGNIAN3YUE20HAOCENGDUIHOUBEIMUZHUJICHUPEIMUZHUZUOXIXIAOBINGDUYIMIAOSHOUCIMIANYIJIEZHONG(YIMIAOWEIWUHANMOUSHENGHUAYOUXIANGONGSISHENGCHANPIHAO071101),ERCHUFABINGLICHUXIANYUJIEZHONGXIXIAOBINGDUYIMIAOYIZHOUHOU,YINCI,ZHONGDIANHUAIYIWEIXIXIAOBINGDUGANRANHUOXIXIAOBINGDUYUYUANHUANBINGDUHUNHEGANRAN。

三、处理措施及效果

1、处理措施

JIANYULISHIWENXIANBINGWUZHILIAOCHUSHENGZIZHUXIANTIANXINGZHENZHANDEYOUXIAOFANGFABAODAO,QIECHUBUHUAIYIWEIBINGDUGANRANSUOZHI,GENGWURENHEYAOWUKEYIZHIJIEDUIFUBINGDUGANRAN,ZHIHAOYICHANGSHIDETAIDUSHIYONGJUYOU“ZHONGGOUDONGWUFEITEYIXINGZHUDONGMIANYIGONGNENG”DEMIANYIDIAOJIEJI—FUYUANKANGA(BUHANRENHEKANGSHENGSUHUOHUAXUEYAOWU),DIYIGEYUEMEIDUNQUANJIASILIAOTIANJIA1.0GONGJIN,DIERGEYUEQIZHUBUDIAOZHENGZHIMEIDUNQUANJIASILIAOTIANJIAJI0.5GONGJIN。CIWAIBINGWUSHIYONGQITARENHEYAOWU。

2、处理效果

5YUE20HAOQIQUANCHANGZAISILIAOZHONGTIANJIAFUYUANKANGA,SHIYONGYIGEYUEZUOYOU,FABINGZHUZHIZHUJIANJIANSHAO,SHIYONGSANGEYUEHOUBINGZHUBUZAICHUXIAN(8YUE20HAOCHUXIANZUIHOUYIWO)。ERQIESHIYONGFUYUANKANGHOU,ZHUQUNJIANKANGZHUJIANHAOZHUAN,SILIAOCAISHILIANGMINGXIANTIGAO,MUZHUCHANHOUMIRUGONGNENGTEBIEHAO,QUANCHANGZIZHUCHENGHUOLVCONGYIQIANDE80%ZUOYOU,TIGAOZHI98%;28TIANDUANNAIJUNZHONGCONG7GONGJINZUOYOUTIGAODAO8.5GONGJIN;SHUYUEHOUJINGUANMEIYOUTIANJIARENHEYUFANGXINGYAOWU,DANZAICHANFANGJIBAOYUSHEJUNJIHUJIANBUDAOYIQIANCHANGJIANDEYIWEILIANQIUJUNJIZHUFUSHIXUEGANJUNGANRANDEZHENGZHUANG;MUZHUDUANNAIHOU3—5TIANNEIJIHUQUANBUFAQINGPEIZHONG,QINGQISHOUTAILVJIPEIZHONGFENMIANLVDAFUTIGAO;GUOQUCHANGJIANDEMUZHUZIGONGNEIMOYANZHENGZHUANGXIANZHUJIANSHAO,GEJIEDUANZHUQUNDELEIBANJIHUWANQUANXIAOSHI(LINCHUANGJINGYANBIAOMING,LEIBANYUZHUQUNZONGHEJIANKANGZHUANGKUANGYOUXIANZHUGUANLIAN),YIMIAOJIEZHONGCONGGUOQUDE9ZHONGJIANSHAOWEI5ZHONG(XIXIAOBINGDU、ZHUWEN、WEIKUANGQUAN、YINAOJI5HAOBINGMIAO);QUANCHANGZHUQUNCUNLANLIANGJIJIANKANGSHUIPINGDADAOJIANCHANGSHINIANLAIDEZUIJIAZHUANGTAI。

四、讨论

1、CHUSHENGZIZHUXIANTIANXINGZHENZHANZONGHEZHENGSHIKUNRAOZHUCHANGGUANLIRENYUANDEWANJI,ZHANGQIYILAIDUIQIBINGYINXIANRUJIHUWUFADACHENGGONGSHIDEZHENGLUNZHIZHONG,CONGBENANLIXIANGXILINCHUANGZHENGZHUANGGENZONGFENXIJIBIZHEGUOWANGSUOJIECHUANLIJUNYOUYIGEGONGTONGDETEZHENG,JIFABINGZHUCHANGJUNYOUXIXIAOBINGDUYIMIAO“YIDAOQIE”JIEZHONGCHENGXU。YINCIKECHUBUPANDUANWEIGAIZHENGZHUANGYUJIEZHONGXIXIAOBINGDUYIMIAOYOUZHIJIEYINGUOGUANXI。

2、JIANYUSHENGCHANSHANGYUANHUANBINGGANRANYIXIANGDANGPUBIAN,HENDUOGUANCHAZHERENWEICHUSHENGZIZHUXIANTIANXINGZHENZHANYUYUANHUANBINGDUGANRANYOUGUAN。DANCONGBENANLIFENXI,QICHUFABINGSHIJIYUZHUQUNJIEZHONGXIXIAOBINGDUYIMIAOSHIJIYOUJINGRENDEWENHEDIAN(JIEZHONGYIMIAOHOUDI8TIANCHUXIANSHOUFABINGLI),ERTONGYICHANGNEIMEIYOUJIEZHONGXIXIAOBINGDUYIMIAODEMUZHUSUOCHANHOUDAIBINGWUFABING,YINCIZAIMEIYOUZUGOUZHENGJUPAICHUYUANHUANBINGDUGANRANWEIQIGONGTONGZHIBINGYINZIDEQINGKUANGXIA,QIMAKEYIQUEDINGXIXIAOBINGDUYIMIAODEJIERUSHIQIFABINGZHIJIEYOUYINHUOGONGYINZHIYI。

3、CONGBENANLIGUANCHAJIEGUOKANLAIJIADINGZAITONGYIHUAIYUNSHENEISIYANGDEMUZHUGANRANYUANHUANBINGDUDEJIHUIJUNDENG,ZEKEYITUIDUANZAIDASHENGCHANTIAOJIANXIA,YUANHUANBINGDUGANRANBINGWEIDAOZHIDANDUYINFAZIZHUXIANTIANXINGZHENZHANZHENGZHUANGDECHUXIAN。

4、接种细小病毒疫苗导致母猪生产出有先天性震颤症状的后代,如果可以排除疫苗佐剂副作用的话,那么是疫苗毒株的孤立作用,还是疫苗毒株与动物体内已感染的圆环病毒互作的结果,抑或是疫苗

DUZHUYUQITAZHIBINGYINZIHUZUODEJIEGUO,SHENZHIMEIYOULIYOUPAICHUYIMIAODUZHUSHIFOUCUNZAIMIEHUOBUWANQUANDEKENENGXING。ZHUDUOYIWENRENGYOUDAIGENGDUODEJINGQUESHIYANJIAYIYANZHENG。

5、JIANYUGAIBINGBIAOXIANZHENGZHUANGWEIQUANSHENGONGJISHIDIAO,QIEZHICHUXIANZAIDONGWUXINGJUEZHUANGTAI,SHUIMIANZHUANGTAIBINGBUBIAOXIANCHURENHEZHENGZHUANG,KECHUBUTUIDUANDONGWUSHOUSUNBINGZAOHENKENENGJUXIANZAIDANAOZHONGSHUYUYUNDONGDIAOJIEXIANGGUANDEHETUANZHONG,ERBUSHIGUOWANGRENMENRENWEIDESHENJINGSUIQIAOFAYUBULIANGDAOZHISHENJINGDIZHICHUANDAOZHANGAI。ZHUNQUEDEJIELUNKEWANGTONGGUODUICHENGGONGFUZHIDEBINGLIZUOBINGLIFENXIERDEDAO。

6、YOUYUMEIYOUSHELIPINGHENGDUIZHAOZU,BENANZHONGGUANCHADAOSHIYONGFEITEYIXINGMIANYIDIAOJIEJI—FUYUANKANGAHOU,KEZHUJIANJIANSHAOFABINGSHULIANGJIZHIZUIZHONGXIAOMIEYOUGUANZHENGZHUANG,JIUJINGSHIOURANDEQIAOHEHAISHIBIRANJIEGUOYIYOUDAIZUOJINYIBUYANZHENG。

7、GUOWANGGUANCHADAO,DONGWUFUYONGFUYUANKANGMIANYIDIAOJIEJIHOU,KEJIHUODONGWUMIANYIXITONGSHIQIHUIFUQIZHENGCHANGGONGNENG,BINGYANSHENGCHUYOUXIAODEMIANYIYINZI,XIAOMIERUQINTINEIDEYUANHUANBINGDU。ZAIBENANZHONGSHIFOUYUCIYOUGUAN,YOUDAIGENGSHENRUDEYANJIUJIAYIYANZHENG。

8、JIANYUXIXIAOBINGDUYIMIAOJIEZHONGYUZIZHUXIANTIANXINGZHENZHANZONGHEZHENGDEFASHENGYOUZHIJIEYINGUOGUANXI,JIANYIZHUCHANGBIMIANCAIQUXIXIAOBINGDUYIMIAO“YIDAOQIE”DETONGMIANCHENGXU,YANGEZHIXINGPEIZHONGQIAN30TIANWANCHENGGAIYIMIAODEYOUXIAOMIANYIGONGZUO。RUGUOZAIHOUBEIMUZHUPEIZHONGQIANYIGEYUEWANCHENGYOUXIAODEYIMIAOJIEZHONG,ZHEIXIEMUZHURENGSHENGCHANCHUYOUQUEXIANDECHUSHENGZIZHU,ZEYINGGAIBAZHUYILIJIZHONGZAIYIMIAOZHILIANGSHANG。

9、长期以来,细小病毒疫苗的免疫效果缺乏可靠的评价手段,现时的抗体检测方法灵敏度不够,重复性太差,因而造成生产上只求完成疫苗免疫过程,不求实际效果的无奈局面,相关科研部门似宜尽快研发出可操作性强的检测手段,以减少与细小病毒感染有关而又不太引起养猪人重视的重大损失。

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